![]() When the protein products of POMC cleavage accumulate in excess, they turn hypothalamic CRH production off - that is, feedback inhibition occurs. The hypothalamus releases CRH in response to physiologic stressors such as pain, as in the postoperative period. ![]() The pituitary gland synthesizes POMC in response to a signal from the hypothalamus that signal being corticotroponin-releasing hormone (CRH). POMC is a large protein that is cleaved into smaller proteins such as beta-endorphin, alpha-melanocyte stimulating hormone (MSH), adrenocorticotropin (ACTH), and others. ![]() However, recent studies suggest cells of the immune system are also capable of beta-endorphin synthesis because immune cells possess mRNA transcripts for POMC 3 and T-lymphocytes, B-lymphocytes, monocytes and macrophages have been shown to contain endorphins during inflammation. ![]() Synthesis, Storage and Secretion of Beta-Endorphinsīeta-endorphins are primarily synthesized and stored in the anterior pituitary gland 2 from their precursor protein proopiomelanocortin (POMC). ![]()
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